COLL 424 |
| Bo Liedberg, Divisions of Sensor Science and Molecular Physics, Divisions of Sensor Science and Molecular Physics, Linköping University, Department of Physics and Measurement Technology, Linkoping, S-58183, Sweden |
| This contribution describes the self-assembly of alkane thiols and disulphides bearing complex tail groups including, e.g. oligo(ethylene glycols), oligosaccharides and polypeptides. A few examples are given where so-called conformational gradients based on oligo(ethylene glycols) are used to study the protein rejecting properties of non-natural surfaces. The same type of gradients is also used to fine tune and optimise the immobilisation and binding characteristics of sensing surfaces relying the biotin/streptavidin platform. A broad spectrum of oligosaccharide terminated thiols and disuphides recently have been synthesized at our laboratory for applications in biosensing and molecular recognition. Oligosaccharide surfaces bearing b-D-Gal-(1→3)-D-GalNAc tails are also used in a biomimetic materials science project aiming at mimicking the properties of anti-freeze glyco proteins (AFGP). Finally I describe a new class of helix-loop-helix polypeptides that can be used as a scaffold for site-selective attachment of, in principle, any type of ligand. A few examples describing their applications in the evergrowing fields of proteomics and receptor mimicking are highlighted |
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Adamson Award Symposium Honoring Dave Allara and Ralph Nuzzo
Division of Colloid and Surface Chemistry |