COLL 70 |
| Robert J. Hamers, Sarah Baker, and Tami Lasseter. Department of Chemistry, University of Wisconsin - Madison, 1101 University Avenue, Madison, WI 53706 |
| The integration of cabon nanotubes with biological molecules opens up new opportunities in nanoscale assembly and in nanoscale biological sensing. We have explored the formation of covalently-bonded adducts of single-walled carbon nanotubes (SWNTs) with biological molecules, and the subsequent interactions of biologically-modified SWNTs with other biomolecules of interest. Our studies focus primarily on the use of DNA hybridization and the biotin-avidin interaction. SWNTs were chemically modified to produce amine-terminated SWNTs, which were then covalently linked to DNA or biotin. DNA-SWNT adducts reversibly hybridize to complementary sequences with little binding to non-complementary sequences, demonstrating that the binding is highly selective. Similar chemistry has been used to link SWNT's to biotin, which then exhibit strong interactions with avidin. The interactions of biologically-modified SWNTs with biomolecules in solution and on surfaces has been explored. Our results illustrate the utility of biomolecular recognition (DNA hybridization and biotin-avidin interactions) to control assembly of nanomaterials. |
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Surface Chemistry on Carbonaceous Materials
Division of Colloid and Surface Chemistry |