COLL 495 |
| Yanxiu Zhou1, Bin Yu2, and Kalle Levon2. (1) Polymer Research Instituite, Polytechnic University, Six MetroTech Center, Brooklyn, NY 11201, (2) Polymer Research Institute, Polytechnic University, Six MetroTech Center, Brooklyn, NY 11201 |
| A chemical sensor consists of two main components: molecular recognition and physical transduction. Integration of these recognition and transduction processes has elegantly been presently in biology by membrane ion channel. In our application, we have combined surface imprinting with proton sensitive nano-scale transducer indium-tin oxide (ITO). We modified the ITO electrode surface and developed imprinted structures on the surface for the molecular recognition. This integrated system was applied to differentiate electrochemically chiral amino acids. The sensors exhibited recognition properties towards one isomer of racemic N-carbobenzoxy aspartic acids (N-CBZ-Asp) without any pre-separation processes. The sensors translated the enantioselective recognition event into a potential change by detecting optically active N-CBZ-Asp in a concentration range of 5.0 x 10-6 – 10-2 M. The enantiomeric selectivity coefficients of the sensors for the counter isomers were in the range of 0.004-0.009. Furthermore, rapid, specific recognition of methylphosphonic acid (MPA), a degradation product of nerve agent Sarin, and dipicolinic acid (DPA), a biomarker of endospores, were also achieved with the same method. The viability of MPA and DPA sensors in the presence of various interferences was investigated.
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Chiral Surfaces
Division of Colloid and Surface Chemistry |