Double Bond - September 1998

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Double Bond
September 1998

Welcome Back Everyone!

Topic:

Use of Virtual Reality and Computer Modeling Tools
Structure-based Drug Design of Antipneumocystis Agents:

Speaker:

Dr. Vivian Cody Senior Research Scientist and Head of
the Molecular Structure and Drug Design Group
Hauptman-Woodward Medical Research Institute

Date:

Tuesday, September 22, 1998

Place:

The Eagle House Restaurant
5559 Main St., Williamsville, NY

Fellowship:

6:00 PM Cash Bar
Dinner:

7:00 PM 3 meal choices @ a cost of $14.00 per person
(1) Open Sliced Top Round of Beef w/ Mushroom Sauce
(2) Roast Turkey Dinner w/Stuffing
(3) Penne Pasta tossed w/olive oil

***********

Editorial

Over thirty people attended the August meeting and cookout held at our home in East Amherst. Thank you all for coming, bringing delicious dishes to pass and being part of this special evening. Without the hard work and support of my wife, Melanie, the evening would not have been possible. Once again, Jim Felger did a fine job of selecting and preparing steaks for the special sandwiches that have evolved as the section's traditional August entree. Melanie and Jim, thanks a lot for your help!

Prior to dinner, a meeting was held to welcome six members to their new Executive Committee offices, discuss current events of the section and to begin planning for the upcoming program year. Comments from the recently received review of our SectionÕs 1997 Annual Report were also shared with the group. The Local Section Activities Committee of the National ACS states, "Your work for National Chemistry Week was terrific", "The detail that you put into the 1997 Annual Report was impressive," and "Western NY is an extremely strong local section". As a section, we're doing the right things. We just need to stay focused and keep up the good work.

In addition to our usual section activities, suggestions were made for some other things we may consider doing over the next program year. Should the section 1) nominate a local company or property as a National Historic Chemical Landmark, 2) nominate a member for the Helen M. Free Award for Public Outreach, 3) prepare special activities for the International Chemistry Celebration to be held in conjunction with National Chemistry Week (11/1 - 11/7/98), and/or 4) have a joint meeting with the Rochester section?

My term as Chair has ended. It was challenging and extremely rewarding. During my term, I was fortunate to be the recipient of support and guidance by Dr. Mariusz Kozik of Canisius. Mariusz, thank you very much for all of your help! The new Chair of the Section is Dr. Troy Wood of UB. I will assist Troy durning the transition into this program year.

Thank you all for supporting me and the WNY ACS.

Mike

***********

About our Speaker:

Dr. Cody is a Senior Research Scientist and Head of the Molecular Structure and Drug Design Group at the Hauptman-Woodward Medical Research Institute, and also holds research faculty positions in the Medical Chemistry Department and the School of Medicine at SUNY/Buffalo and in the Biophysics Department of the Roswell Park Cancer Institute's Graduate Program.

Abstract:

The focus of this presentation is on the results of crystal structural data for inhibitor bound complexes of enzyme dihydrofolate reductase from human and Pneumocystis carinii sources. Modeling and computational experiments include conformational analysis of anticancer and antipneumocystis antifolates using computer graphics techniques, including prototype virtual reality tools. New antifolates have been synthesized that show biological selectivity for the pneumocystis enzyme and are potential lead compounds for the treatment of the pnemonia prevelant among AIDS patients.

*************

Congratulations

To our new ex-committee officers

Chair
Troy Wood

Vice-Chair
Dr. Luis A. Colon

Secretary
Dr. Nancy R. Gleason

Councilor
David Nalewajek

Member-at-Large Niagara Falls 1999-2000
Dr. Curt Mancuso

Chair Elect
Dr. Mary McCourt

********

State University of New York at Buffalo
OxChem
Chemistry Colloquia
Fall Semester 1998
Fridays in Room 205 NSM Complex at 4:00 PM*
Refreshments in Room 306 NSM Complex at 3:30 PM
unless otherwise noted

August 28
Professor Stephen Glover, University of New England, Australia The Reactivity and Biological Activity of Novel Mutagens N-acyloxy-N-alkoxyamides

September 4
Professor 0mowunmi A. Sadik, University at Binghamton Rational Design of Chemical and Biological Sensors

September 11
Professor Martin Moskovits, University of Toronto Chemically Produced Nanowire Arrays - Towards Device Applications

September 18
Professor David Rose, University of Toronto Probing the Catalytic Mechanism of P-Glycosidases through Structural Studies of Covalent Intermediates

September 25
Dr. David Brown, McMaster University The Chemical Bond in Inorganic Chemistry

October 2
Professor Philip DeShong, University of Maryland New Coupling Technologies: Applications to Synthesis

October 9
Professor Lynn Francesconi, Hunter College Rare Earth Complexes of Polyoxoanions

October 15
Professor Michael Fried, Pennsylvania State University Medical Center Joint with Biology Physical Mechanisms in Gene Regulation

October 16
Professor Carlos R. Cabrera, University of Puerto Rico Title to be announced

October 23
Professor Bernhard Schlegel, Wayne State University Exploring Potential Energy Surfaces for Chemical Reactions Using Ab Initio Molecular Orbital Calculations

October 30
Professor James Cowan, Ohio State University Joint with Biology) Metals and Nucleic Acids. New Perspectives on Nuclease Chemistry and Drug Design

Physical Organic Minisymposium (supported by UB Conferences in the Disciplines)

November 6 (2:00-6:00 pm)
Professor Peter Wan, University of Victoria
Photochemical Methods for the Generation of Quinone Methides
Professor Andrew Bennet, Simon Fraser University
Homoallylic Carbenium and Nitrenium Ions: Structure Reactivity Correlations
Professor Joseph Lambert, Northwestern University
New Organosilicon Molecules
Professor Charles Perrin, University of California, San Diego
Symmetry of Hydrogen Bonds in Solution

November 13
Dr. Bradley Coltrain, Eastman Kodak Co. Organic-Inorganic Composite Films

November 20
Professor Michael Gross, Washington University Mass Spectrometry in Peptide and Protein Chemistry: Biophysical and Bioanalytical Application of H/D Exchange

December 4
Professor Thomas Kalman, University at Buffalo Mechanism-Based Inhibition of Thymidylate Synthase

Schedule subject to change. Call 716-645-6800 for rescheduled or cancelled seminars.*

**

ACS Store goes Online with Local Section and Division Award Products In April of this year, ChemCenter, the one-stop Web site for chemical professionals in industry, academe, and government worldwide, of the American Chemical Society, went online to bring itÕs members many ACS branded items at reasonable prices, with the convenience and safety of ordering through the Internet. Now the ACS Store has added a new catalog of items especially for Local Sections and Divisions to use in their recognition efforts.

Stop by ChemCenter at http://www.ChemCenter.org and check out the new Local Section and Division Awards catalog. This portion of the ACS Store features plaques, banners, certificates, past-chair pins and ACS emblems to make ordering your recognition items as easy as a few keystrokes and mouse clicks! All prices include shipping and will be delivered to your door via UPS.

For more information on ChemCenter or the ACS Store, visit the web site at http://www.ChemCenter.org or call 1-800-227-5558.

1998 Chemical Engineering Graduate Research Symposium
Department of Chemical Engineering
University at Buffalo (UB)
State University of New York (SUNY)
October 21, 1998
Student Union, Room *
North (Amherst) Campus

3:00-4:00pm
Dr. Norman Wagner, University of Delaware
Seminar on"Liquid Crystalline Polymers (LCP) and LCP-Containing Blends"

4:00-4:15pm
Dr. Carl R. F. Lund, Chairperson
Overview of the UB Chemical Engineering department

4:15-5:30pm
Poster Session
All chemical engineering graduate students will participate. The ongoing research activities in the department will be showcased. Faculty will also be available for discussion. Wine and cheese will be served.

5:30pm
"Best Poster" Award and Closing Remarks
For more information feel free to contact any of the members of the organizing committee

P. Alexandridis tel: (716) 645-2911 x2210
S. Andreadis tel: (716) 645-2911 x2204
A. Gupta tel: (716) 645-2911 x2221
S. Neelamegham tel: (716) 645-2911 x2220
M. Swihart tel: (716) 645-2911 x2205
Room TBA Contact Darlene Innes @ 645-2911 x2202

A Cyberspace Science Milestone: All ACS Journals Now on the ÔNet

The launch of 25 Web editions means new features, greater comprehensives, and flexibility for subscribers.

The ACS Publications Division has announced that-for the first time-Internet editions of all 25 of its prestigious journals are available. Officially launched at the ACS National Meeting in Las Vegas, these Web versions include interactive features not available in the print journals and a wide range of subscription options.

"We're providing our members and other scientists with what they've been asking for-Web access to all our journals," said Robert Bovenschulte, director, ACS Publications. "Few, if any, other scientific publishers can match the combination of new features, comprehensives, and flexibility we offer on the Web."

The ACS Web editions contain:

Two separate formats to view articles: interactive text (HTML) and complete page image (.pdf). Users can search and print articles from the entire database starting from 1996 to the present.

Interactive links to other recognized databases. These include Medline, the Protein Database, GenBank, and Chemport.

Articles ASAP (as soon as published). Beginning in January 1998, ACS will post journal articles on the Web as soon as they have been peer reviewed, copy edited, and checked by authors for accuracy. That will allow subscribers to see "published" articles several weeks before they appear in the pages of a printed journal.

"The editions come with flexible pricing, so subscribers pay only for as much or as little information as they need," said Bovenschulte.

For ordering and price information call 1-800-333-9511 or 1-614-447-3671, or travel to the ACS home page and click on "About Electronic Editions" at http://pubs.acs.org.

Senior Chemists

If you need any information please call:

Emil (Inde) Inderbitzen

636-7885

Hank Heubusch

632-0346

AMHERST CHEMISTRY STUDENT EARNS GOLD MEDAL AT INTERNATIONAL COMPETITION IN AUSTRALIA. PLACES SECOND IN THE WORLD.

Tom Snyder, from Amherst Central High School, a student of Mr. Paul Graf, won the gold Medal at the 1998 International Chemistry Olympiad (IChO) in Melbourne, Australia. The announcement was made by Dr. Mariusz Kozik, associate professor of chemistry at Canisius College, local IChO coordinator. A total of 184 students representing 47 countries participated in this year's competition. The top 22 students received gold medals. Tom Snyder was ranked in the 2nd place overall among gold medal winners, which is the highest ranking ever of any student from the United States at the IChO!

In the WNY tradition of outstanding success in the IChO, Tom Snyder is the fifth medal winner from WNY in the international finals since the region entered the competition in 1985. Past medal winners include a gold, a silver, and two bronze medalists. Only two (out of 145 participating) other sections in the U.S. have a better record, and the higher ranked sections include regions of the U.S. with much larger populations.

The Western New York Section's participation in the IChO was sponsored by the Allied Signal Inc., E.I. Du Pont de Nemours & Co., the Chemistry Department of Canisius College, Stark Associates, Wilson Greatbatch, Praxair, Ecology and Environment, OxyChem, and CRA Services.

The 1999 IChO will be held in Thailand.

R.E.A.C.T.

Date:
Sept. 26, 9:00 AM-12:00 Noon

Location:
Canisius College

Building:
Horan O'Donnell, Room S-015

Speaker:
Helen Domske
Specialist Great Lakes Eco Systems

Topic:
Discussion & Activities Concerning the Great Lakes
And New York Sea Grants

Upcoming Dates to Keep in Mind:

Date:
Oct. 31, 9:00 AM-12:00 Noon

Location:
Canisius College

Building:
Horan O'Donnell, Room S-015

Speaker:
Dave Copeland
Chair of Education Committee
Waste Management

Topic:
TBA

Dates:
Nov. 21 & Dec. 12 Locations will be announced

If you need any information please call:

Karen Arnold 884-5894 (one week prior to workshop)

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