36th Middle Atlantic Regional Meeting (MARM)
June 8-11   2003
Spnsored by the Trenton ACS Section and
Princeton University


Confirmed Speakers: Medicinal Chemistry II
in silico ADME/Tox:
Problems and issues from modeling and experimental perspectives


Chair: Dr. T. Stouch Bristol Myers Squibb


Bristol Myers Squibb




Aventis Pharmaceuticals



Astra-Zenica



Accelrys Inc.


The aim of the symposium will be to discuss issues and problems with in silico modeling of ADME endpoints. We will discuss where models fail and where they work, and why; the required quality of the the data; and the needed precision and accuracy of the endpoints. We plan to include experimentalists in the symposium to discuss the accuracy and precision of ADME screening methods and to come to an understanding of the synergy and interface between the in silico, in vitro, and in vivo modeling. We plan for this to be at least a one day symposium of 8-10 talks plus discussion. It is hoped that we will be able to afford to defray the travel expenses of several of the leaders of the field in order to make this a state-of-the-art symposium with results, not just presentions.
Printed Program Id Author Name Author Institution Title Presentation Time Building Room
101 Christopher Lipinski Pfizer Global R&D, Groton Labs (retired) SOLUBILITY LIMITATIONS IN CACO-2 PERMEABILITY TESTING Tuesday, Jun 10 2003 9:00AM Jadwin JA10
102 Saeho Chong Bristol-Myers Squibb Pharmaceutical Research Institute FACTORS INFLUENCING PRECISION/ACCURACY OF PERMEABILITY DATA ACROSS INTESTINAL MEMBRANE Tuesday, Jun 10 2003 9:45AM Jadwin JA10
- - - Coffee Break 10:30-10:45 - -
103 Kenneth Santone Bristol-Myers Squibb Pharmaceutical Research Institute Preclinical ADME Screening Databases: Modeler's Dream or Computational Nightmare? Tuesday, Jun 10 2003 10:45AM Jadwin JA10
107 Troy Bremer Lion Biosciences Inc Considerations and challenges for In silico ADME models and their use in Drug Discovery. Tuesday, Jun 10 2003 3:00PM Jadwin JA10
- - - Lunch 12:15-1:30 - -
105 Yvonne Martin Abbott Laboratories ADME PREDICTION FROM STRUCTURE: A CASE OF THE EMPEROR’S CLOTHES? Tuesday, Jun 10 2003 1:30PM Jadwin JA10
106 Alexander Tropsha University of North Carolina at Chapel Hill DEVELOPMENT OF PREDICTIVE QSPR MODELS WITH APPLICATIONS TO DATABASE MINING. Tuesday, Jun 10 2003 2:15PM Jadwin JA10
104 Roy Vaz Aventis Pharmaceuticals A CHEMIST'S VIEW OF THE HERG ION CHANNEL Tuesday, Jun 10 2003 11:30AM Jadwin JA10
- Steve Johnson Bristol-Myers Squibb A panel discussion with the day's speakers to address common and pertinent points and solutions. 3:45-5:00PM Jadwin A10



Last modified: Thu May 22 15:16:25 2002