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INTERNATIONAL
AWARD
FOR RESEARCH IN AGROCHEMICALS
PRESENTED BY THE AGROCHEMICAL DIVISION OF ACS
SPONSORED
BY BASF CORPORATION
 Dr.
Frederick J. Perlak will receive the International Award for
Research in Agrochemicals for his work in the discovery,
development, and commercialization of insect-protectedcrops.
Through his efforts and those of his colleagues at Monsanto Company, Bollgard® cotton
was developed and introduced in 1996, and became one of the first commercially
successful plant products that could protect itself from damage
by insect pests. The
use of insect
control in
planta proteins
as agrochemicals provided farmers with a new technology
that offered many benefits
over the existing insecticide products. Similar strategies
have been applied in other crops such as corn and as
a result insect-protected crops are now grown in at
least nine countries including India, China, the Philippines,
Australia, South Africa as well as
the United States providing economic and environmental benefits
for large and smallholder farmers.
Fred
grew up in Springfield,
Massachusetts and received his Bachelor of Science
degree in Biology at Fairfield University in Fairfield,
CT. He received his Ph.D. in Microbiology from the University
of Massachusetts in Amherst, MA. Following a post-doctoral
appointment at Ohio State University, he joined Monsanto
Company in 1981 within the Agricultural Division as a
research scientist focused on the isolation and characterization
of genes that code for proteinaceous insect toxins.
In
April 1991, Dr. Perlak and his colleagues at Monsanto published
a key paper in the Proceedings of the National Academy
of Science 88:3324-3328 in which they described a breakthrough
in the development of genetically improved plants with
acceptable levels of insect resistance. Under Fred’s
leadership the team modified the nucleotide sequence of
the gene, cry1A(c), for an insecticidal protein from Bacillus
thuringiensis (Bt) and achieved up to a 100-fold increase
in the levels of Cry1A(c) protein responsible for insect
protection. This technical advance made possible the development
and future commercial success of Bollgard® cotton and
other Bt crops.
In 1993, Fred was appointed a Monsanto
Fellow in recognition of his technical achievements and
became Project Team Coordinator and Technical Leader for
Insect Resistant Potatoes and Insect Resistant for Cotton
and Specialty Crop Technology and Distinguished Fellow.
Fred Perlak is the author or a coauthor of numerous scientific
articles in a broad cross section of peer reviewed journals
including Proceedings of the National Academy of Science,
Journal of Food and Agricultural Chemistry, The Plant Journal,
Plant Molecular Biology, and Bio/Technology. In 1999, Fred
was named the Alfred M. Boyce Lecturer at the University
of California-Riverside Department of Entomology and in
2000 he was presented the Friend to Indian Cotton Farmer
Award by the Federation of Indian Farmers for his efforts
to commercialize insect-protected cotton in India. Also
in 2000, Fred
received the Edgar M. Queeny Award for Science and
Technology, the highest award within Monsanto for scientific
achievement.
An all-day symposium to honor Dr. Perlak will be held on
Tuesday, August 21.
|
INTERNATIONAL AWARD
FOR RESEARCH IN AGROCHEMICALS
PRESENTED BY THE AGROCHEMICAL DIVISION OF ACS
SPONSORED BY DUPONT CROP PROTECTION
 Dr.
Gerald T. Brooks will receive the International Award for
his work on insecticide biochemical toxicology and
for his
sustained contributions to the publication of agricultural
research. Dr. Brooks received his BSc in Chemistry in 1953
and his PhDin 1956 from London University. In 1986 he was
awarded a DSc, also from London University, for his studies
on structure-activity relationships, the mode of action of
insecticides, and insect growth regulators.
Dr. Brooks became a Civil Service Senior Research
Fellow in the Biochemistry Department of the Pest Infestation
Laboratory in Slough, UK in 1956. He became a Senior Scientific
Officer in 1961 and served as the Principal Scientific Officer
in Biochemistry Department from 1964 to 1969 and then at
the Unit of Invertebrate Chemistry and Physiology of the
former Agricultural Research Council (ARC, now incorporated
into the Biotechnology and Biological Sciences Research Council)
at the University of Sussex, where he was Senior Principal
Scientific Officer; Head of ARC Insect Chemistry and Physiology
Group at Sussex from 1982; and Honorary Reader of University
of Sussex. Subsequent to his retirement in 1987, Dr. Brooks
was a Visiting Research Fellow in the Biochemistry Department
of Reading University, UK until 1991.
Dr. Brooks has been a Fellow of the Royal Society of Chemistry
(RSC) since 1966 and was a member of the RSC’s Agriculture
Group Committee from 1989 to 1996. In 1981, he became a Fellow
of the Institute of Biology and served as a Member of Council
from 1985-1989. Dr. Brooks is an emeritus member of the Biochemical
Society and the International Society for the Study of Xenobiotics;
a member of the Pesticide Science Society of Japan and the
British Toxicology Society; and a former member of the AGRO
Division of ACS. He was also a member of the British Crop
Protection Council from 1990 to 2002 and received the Distinguished
Service Award of the Society of Chemical Industry in 2002.
Dr. Brooks has been a member of the Society of Chemical
Industry (SCI) since 1969 and of the SCI Pesticides Group
(now Pest Management Group) Committee from 1974. He has served
on the Pesticide Science Editorial Board since 1976, as the
Editorial Board Vice Chairman, as Editorial Board Chairman,
and as Editor-in-Chief of the journal when it was renamed
Pest Management Science in 2000. He is also a member of the
International Advisory Board of Outlooks on Pest Management
(Pesticide Outlook). Dr. Brooks has served as a member of
editorial boards for other journals including Pesticide Biochemistry
and Physiology; Journal of Biochemical Toxicology; Journal
of Environmental Health Science, B (Pesticides, Food Contaminants,
and Agricultural Wastes); and Agriculture, Ecosystems, and
Environment. |
INTERNATIONAL
AWARD
FOR RESEARCH IN AGROCHEMICALS
PRESENTED BY THE AGROCHEMICAL DIVISION OF ACS
SPONSORED
BY BASF CORPORATION
 Dr.
Isamu Yamaguchi has been the president of theAgricultural
Chemicals Inspection Station (IncorporatedAdministrative
Agency) since April 2005. He is an advisorfor the 11th
IUPAC International Congress of Pesticide Chemistry held
in Kobe, Japan, August 2006. He has beena member of the
Agrochemicals Division for 20 years.
Dr.
Yamaguchi graduated from the Department of Agricultural
Chemistry, finished the master course of Graduate School
of Agriculture (Antibiotics) at The University of Tokyo,
and joined RIKEN (The Institute of Physical and Chemical
Research) in 1967. He obtained his Ph.D. from The University
of Tokyo by presenting the thesis entitled, “Studies
on the Metabolic Fate of Blasticidin S in the Environment.” Blasticidin
S deaminase found in this study is a novel nucleoside deaminase.
The successful cloning of its responsible genes, BSD and
bsr, opened a new aspect of blasticidin S as a useful research
agent in molecular biology. The BSD gene has been widely
used in the world as a drug selectable marker.
Dr. Yamaguchi was a research associate at the University of Wisconsin and Michigan
State University engaging in research on the action mechanism of heptachlor
epoxide on synaptic ATPases in Dr. Matsumura’s laboratory (1976 – 1979).
After returning to Japan, he conducted research on the interaction between
plants and microorganisms and on plant disease control. He and co-workers obtained
fruitful results on the action mechanism of non-fungicidal chemicals to control
the rice blast disease, such as melanin biosynthesis inhibitors and the chemicals
to induce systemic acquired resistance, metabolic degradation of persistent
chemicals by rhizospheric microorganisms, and molecular breeding of disease-resistant
plants.
Dr.
Yamaguchi was appointed as the chief scientist of Microbial
Toxicology Laboratory, RIKEN in 1985, and from 2000 to
2005, he served as a group director of Environmental Plant
Research Group at RIKEN Plant Science Center. He was appointed
as a visiting professor at the Graduate School of Saitama
University, Toyo University, Tokyo University of Agriculture,
University of California at Davis, Louis Pasteur University,
and Zhejiang University of Technology. He was also invited
as a lecturer at Tsukuba University, Nihon University,
Chiba University ,and Tokyo University of Agriculture and
Technology. Dr. Yamaguchi has served as an executive committee
member of Pesticide Science Society of Japan and as president
of the Society from 1999 – 2001. He has also served
as the council member of the Phytopathological Society
of Japan and of the Japan Society of Bioscience, Biotechnology,
and Agrochemistry. He has written over 250 research and
review papers. |
INTERNATIONAL
AWARD
FOR RESEARCH IN AGROCHEMICALS
PRESENTED BY THE AGROCHEMICAL DIVISION OF ACS
SPONSORED BY DUPONT CROP PROTECTION
 Joel
Coats is Professor of Entomology and Toxicology, in the Department
of Entomology at Iowa State University. He is originally from
Kenton, Ohio, and he received his B.S. in Zoology (Chemistry
minor) from Arizona State University. He went to graduate
school at the University of Illinois at Urbana-Champaign,
receiving his M.S. and Ph.D. in Entomology (Chemistry minor),
with specialization in insecticide toxicology and environmental
toxicology. Professor Robert L. Metcalf served as his major
professor there. He was a Visiting Professor for two years
in the Department of Environmental Biology at the University
of Guelph in Ontario, Canada.
Since 1978 he has served at Iowa State University, as Assistant,
Associate, and Full Professor, and as Department Chairman
for five years. He also was Guest Scientist at the Forschungszentrum-
Jülich in Germany for six months. At Iowa State, he was
the primary organizer of the Interdepartmental Toxicology
Graduate Program and served as the first Chair of that program.
He teaches all or parts of six graduate courses: Insecticide
Toxicology, Pesticides in the Environment, Special Topics
in Insect Toxicology, and small parts of Principles of Toxicology,
Laboratory Methods in Toxicology, and Natural Toxins.
Joel
has had the opportunity to mentor many excellent graduate
students and postdocs, and most have continued to have significant
impact in the field after they have graduated from his laboratory.
He has served as major professor for 41 graduate students
(including 8 current ones) and as adviser for 12 postdocs.
Joel’s
research program includes two main areas: (1) environmental
toxicology and environmental chemistry of agrochemicals and
(2) insect toxicology. The first topic addresses environmental
effects and environmental degradation and mobility of modern
agrochemicals, including conventional and natural insecticides,
herbicides, insecticidal Bt protein toxins from transgenic
plants, and veterinary drugs. His research in the insect toxicology
area is focused primarily on natural products as insecticides
and insect repellents, including investigations of their activity,
modes of action, selectivity, metabolism, identification,
synthesis of derivatives and analogs, and quantitative structure-activity
relationships. Dr. Coats’ research has covered the spectrum
from very applied to very basic studies. His scientific publications
include 7 books, 6 review articles, 30 book chapters, and
112 peer-reviewed journal articles; he also holds 7 patents.
Joel
is extremely proud of his former graduate students and postdocs
and the excellent contributions they are making to the agrochemicals
field, e.g., in industry, government, and academia. He is
also very proud of his wonderful family, including his wife,
Becky, their five children, Sarah, Jesse, Beth, Aaron, Annie,
and two grandchildren, Leola and Chloe. He is appreciative
of their understanding, support and encouragement over the
years.
|
INTERNATIONAL
AWARD
FOR RESEARCH IN AGROCHEMICALS
PRESENTED BY THE AGROCHEMICAL DIVISION OF ACS
SPONSORED BY DUPONT CROP PROTECTION
 Janice
E. Chambers is the Director of the Center for Environmental
Health Sciences, and is a William L. Giles Distinguished Professor
in the College of Veterinary Medicine, Mississippi State University.
She is originally from Berkeley, California. She holds an
undergraduate degree in Biology from the University of San
Francisco, and a Ph.D. in Animal Physiology from Mississippi
State University. She held post-doctoral positions at Mississippi
State University.
Jan has been the Principal Investigator of over $20 million
in federally-funded competitive grants in the field of toxicology,
with current or previous support from NIH, EPA, NSF and the
American Chemistry Council. She has served on a number of
advisory boards and committees, including the National Research
Council Board of Toxicology, the International Life Sciences
Institute/Health and Environmental Sciences Institute, the
Society of Toxicology and the American Chemistry Council.
She is or has been a peer review panel member for NIH and
NIOSH, and a member of journal editorial boards. She has previously
served for 3 years as Secretary for the Agrochemicals Division
and has participated in AGRO program planning. She has held
a number of committee positions in the Society of Toxicology
and is currently the Secretary-Elect. She has received a Burroughs
Wellcome Toxicology Scholar Award and a SmithKline Beecham
award for Research Excellence, along with research awards
at MSU. She is board certified in general toxicology by the
American Board of Toxicology and she is a Fellow of the Academy
of Toxicological Sciences. She is currently serving as a member
of EPA’s permanent Scientific Advisory Panel for FIFRA.
The Center for Environmental Health Sciences at MSU, which
Jan directs, is an interdisciplinary research center specializing
in pesticide toxicology and is supported primarily by the
National Institutes of Health. This center has about 30 faculty,
staff and students associated with it. Its research areas
are neurotoxicology, biochemical toxicology, analytical chemistry,
biostatistics, epidemiology, computational chemistry, computational
simulation, biochemistry and endocrinology. Jan directs a
mechanistic research program specializing in pesticide toxicology
with a major emphasis on organophosphorus insecticides, and
she has been involved in the training of about 40 graduate
students and post-docs. She directs several research projects
on the effects of pesticides in mammalian systems to identify
the potential human health effects of pesticide exposures,
and is primarily interested in the biochemical determinants
of toxicity levels in adult and developing animals; her research
addresses a number of FQPA issues. Her program emphasizes
a consideration of the dose-response relationships, and for
making predictions of toxicity based on realistic levels of
pesticide exposure. Specifically there are projects related
to the neurochemical and behavioral effects of pesticides
in developing organisms; the metabolism of pesticides in developing
organisms; effects of chemical mixtures and the development
of data related to cumulative risk assessment; mathematical
predictions of the effects of mixtures; and exposure assessment
of children and adults from contact with a pet dog which has
been treated with flea control insecticides. Jan has a long-term
professional relationship with her husband, Howard Chambers,
of MSU’s Entomology and Plant Pathology Department,
which has yielded joint grants, publications, and students,
and many mechanistic conversations. The personal side of the
relationship has yielded two beautiful and talented daughters,
Kristen and Cheryl. |
| INTERNATIONAL
AWARD
FOR RESEARCH IN AGROCHEMICALS
PRESENTED BY THE AGROCHEMICAL DIVISION OF ACS
SPONSORED
BY BASF CORPORATION
 Dr.
Robert Krieger has conducted a program of excellence in assessing
and reducing exposures and risks associated with the use of
pesticides, and communicating this information to student,
professional, and lay audiences. He and his many collaborators
have defined the principles and developed the methodology
needed for conducting exposure studies that underpin the assessment,
reduction, and communication of risks. His work with exposure
to soil fumigants and chemicals used for orchard pest control,
particularly organophosphates, typifies his accomplishments.
The results have been used in setting regulations, in extension
courses he and others have given for pesticide formulators,
applicators, and field workers, and in responding to concerns
from urban and rural populations. His firm belief that effective
risk management requires accurate determination of dose and
time to evaluate the health significance of chemical exposures
permeates his research in the 'Personal Chemical Exposure
Program' which he established and directs at the University
of California. Research focuses on the development and use
of advanced analytical methodology to identify fate and movement
of pesticide residues from environmental compartments to children
and adults. Indoor, turf, and field settings have been included.
In agriculture this research has supported development of
exposure-based reentry times, as opposed to adverse effect
based reentry times used prior to implementation of the risk
assessment process. Effective reentry times require accurate
human exposure data and clear definition of work tasks so
that short-term and long-term adverse effects can be considered.
He continues to investigate the relationship between dislodgeable
foliar residues and the bioavailability of those residues
to harvesters based upon biomonitoring of urine and blood.
A linear plant exposure chamber was developed for use in predictive
structure-activity relationships. His research explores chemical
transferability of chemical residues with respect to chemical
(active ingredients as well as adjuvants) as well as from
physical (adsorption, particularly cuticular waxiness in the
case of plants) characteristics. Recent human studies have
included assessment of the effects of perspiration on skin
absorption, transfer and absorption of pyrethroids from indoor
carpeting, human perchlorate exposure from food and water,
and an exposure assessment of triclopyr and 2,4-D herbicides
during backpack application in forestry.
Bob is a Cooperative Extension Toxicologist in the Department
of Entomology, University of California, Riverside. He holds
a B.S. in Chemistry from Pacific Lutheran University (1967)
and a Ph.D. from Cornell University (1970) where he was a
student in the Department of Entomology and an NIEHS Trainee
in Environmental Toxicology. He has held tenured academic
appointments at University of California, Davis (1971-1980)
and in the Washington-Oregon-Idaho Regional Veterinary Medical
Education Program (1981-1986) where he was Professor of Veterinary
and Comparative Toxicology. In 1986 he became a staff toxicologist
and later Branch Chief of Worker Health and Safety, California
Department of Food and Agriculture (now California EPA). Krieger
served two major Washington, D.C. consulting firms (1991-94)
in exposure and risk assessment before returning to the University
of California as an extension Toxicologist (1994-present)
specializing in pesticide exposure assessment and worker health
and safety. He has taught toxicology at both the undergraduate
and graduate levels and received several teaching awards including
the Society of Toxicology's Education Award.
He has organized and participated in numerous symposia of
ACS, IUPAC, the Society of Toxicology, and other scientific
societies, and authored/coauthored over 250 published papers,
book chapters, and abstracts, including serving as editor
for the comprehensive Handbook of Pesticide Toxicology, issued
in 2001. He has trained a generation of environmental toxicology
students who hold important positions in academia, government,
and industry. Bob resides in Riverside, CA, with his wife
Lee and son William.
|
INTERNATIONAL
AWARD FOR RESEARCH IN AGROCHEMICALS
PRESENTED
BY THE AGROCHEMICAL DIVISION OF ACS
SPONSORED
BY DUPONT CROP PROTECTION
 Dr.
John Marshall Clark, Ph.D., is a professor of environmental
toxicology and chemistry in the Department of Veterinary &
Animal Science at the University of Massachusetts in Amherst.
He is the director of the Massachusetts Pesticide Analysis
Laboratory and an adjunct professor in the Molecular and Cell
Biology, Environmental Toxicology & Risk Assessment, and
Plant
Biology Programs. He has made numerous contributions to the
study of agrochemicals and has been an active member of the
Agrochemical Division of ACS for 28 years. He also is a member
of the Environmental Chemistry and Chemical Toxicology Divisions
of ACS. Dr. Clark’s research has contributed substantially
to the basic understanding of pesticide mode of action, resistance
mechanisms and management, and environmental fate and exposure
assessment. He has published over 150 research and review
articles and edited six symposium books.
John has extensively studied the manner in which neurotoxic
pesticides affect both target and non-target organisms, including
long-term investigations focused on alternative modes of action
of the pyrethroid insecticides. This research has established
that CS-syndrome pyrethroids, in addition to their action
at voltage-sensitive sodium channels, also modify the kinetics
of voltage–sensitive calcium channels at presynaptic
nerve terminals, evoking n//eurotransmission. Recent investigations
have begun the evaluation of mixtures of pyrethroids in terms
of their agonistic and antagonistic effects at these target
sites. This unique action of only some pyrethroids will have
a substantial impact on their characterization using FQPA
criteria.
He
has also made many contributions to the elucidation of resistance
mechanisms of insects. John is one of the pioneers in the
implementation of molecular techniques (e.g., Bi-PASA, minisequencing,
SISAR, RT-PCR, etc.) as practical genotyping tools for monitoring
resistance in field populations.
Dr. Clark has directed the Massachusetts Pesticide Analysis
Laboratory since 1984 and, in addition to FIFRA/FQPA enforcement
aspects, has conducted research that addresses critical concerns
that occur as urbanization encroaches on agricultural areas.
His analytical research group has contributed new methodology
for pesticide analysis and identification of active metabolites,
means to detect and evaluate chemical trespass following the
application of pest control agents, and the critical evaluation
of recreational exposures following application of turfgrass
chemicals using combined environmental residue, dosimetry
and biomonitoring approaches.
John
has been active in various other professional societies (SOT,
SFN, SETAC), serves on four editorial boards of scientific
journals, and has served on many grant review panels (NIH,
EPA, NSF, USDA). He is currently a member of the scientific
program committee for the 11th IUPAC International Congress
of Pesticide Chemistry, Kobe, Japan 2006. |
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